Key result
Surgically induced lipid malabsorption via modified biliopancreatic diversion drastically lowered plasma triglycerides and reduced fasting plasma glucose from 17 to 5 mmol/l.
Why the study?
Does modified biliopancreatic diversion improve glycemic control in patients with extreme hypertriglyceridemia and insulin-resistant diabetes?
Population
Two sisters with extreme hypertriglyceridemia and overt diabetes due to familial lipoprotein lipase…
Comparison
Modified biliopancreatic diversion to surgically… vs Prior failed medical therapy including high-dose…
Design
Case_series
Follow-up
3 weeks post-surgery and throughout observation period
Authors
Loading...
Extreme hypertriglyceridemia may drive reversible insulin resistance; case-report data leave open need for prospective confirmation.
Case Report (n=5)
Does modified biliopancreatic diversion improve glycemic control in patients with extreme hypertriglyceridemia and insulin-resistant diabetes?
Absolute Event Rate: 5% vs 17%
Surgical normalization of triglycerides via modified biliopancreatic diversion cured insulin-resistant diabetes in two patients with extreme hypertriglyceridemia, providing evidence that extremely high TG levels can cause insulin-resistant diabetes.
Mingrone et al. (1999) conducted a case report in Extreme hypertriglyceridemia and overt diabetes (n=5). Modified biliopancreatic diversion vs. Baseline (medical therapy including high-dose insulin) was evaluated on Fasting plasma glucose levels (mmol/l). Surgically induced lipid malabsorption via modified biliopancreatic diversion drastically lowered plasma triglycerides and reduced fasting plasma glucose from 17 to 5 mmol/l.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: