April 1, 2019BMJ Case ReportsOpen Access

Severe hypertriglyceridaemia and pancreatitis in a patient with lipoprotein lipase deficiency based on mutations in lipoprotein lipase (LPL) and apolipoprotein A5 (APOA5) genes

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Why the study?

Does dietary triglyceride restriction and discontinuation of oral contraceptives reduce plasma triglycerides in a patient with severe hypertriglyceridaemia and LPL/APOA5 mutations?

Population

A 44-year-old woman with pancreatitis caused by hypertriglyceridaemia

Design

Case report

Follow-up

2 weeks

Authors

CKCharlotte KoopalUtrecht University RBRemy H.H. BemelmansÇevre ve Şehircilik Bakanlığı AMA. David MaraisUniversity of Cape Town

Discussion

Member takes

Implication

May support low-fat diet plus OC cessation in genetic hypertriglyceridaemia; leaves open prospective validation.

Structured PICO

Does dietary triglyceride restriction and discontinuation of oral contraceptives reduce plasma triglycerides in a patient with severe hypertriglyceridaemia and LPL/APOA5 mutations?

Population

1 patient (n=1), 44-year-old woman with severe hypertriglyceridaemia (fasting triglycerides 28 mmol/L) and pancreatitis, overweight (BMI 29.7 kg/m2), using oral contraceptives and ezetimibe 10 mg, with mutations in LPL and APOA5 genes.

Intervention

Dietary triglyceride restriction and discontinuation of oral contraceptives (initially treated with gemfibrozil but discontinued due to side effects).

Outcome

Plasma triglyceride levelssurrogate

Near-normal triglyceride values can be achieved with a low-fat diet and discontinuation of oral contraceptives in patients with severe hypertriglyceridaemia due to genetic mutations.

Cite This Study

Koopal et al. (2019) studied this question.

synapsesocial.com/papers/6a7fc17ffeefc34aa4422532 https://doi.org/10.1136/bcr-2018-228199

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Severe hypertriglyceridaemia and pancreatitis in a patient with lipoprotein lipase deficiency based on mutations in lipoprotein lipase (LPL) and apolipoprotein A5 (APOA5) genes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Severe hypertriglyceridaemia and pancreatitis in a patient with lipoprotein lipase deficiency based on mutations in lipoprotein lipase (LPL) and apolipoprotein A5 (APOA5) genes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider