Key result
Insulin deficiency caused a 70% decrease in lipoprotein lipase secretion by murine macrophages, which was partially reversed by insulin treatment.
Why the study?
Does insulin deficiency or treatment affect lipoprotein lipase secretion by murine macrophages?
Population
Murine macrophages isolated from streptozocin-induced insulin-deficient mice and control mice
Comparison
Insulin treatment vs Control mice and untreated insulin-deficient mice
Design
Preclinical
Follow-up
1 week
Authors
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Hypothesis-generating for macrophage LPL in diabetic atherosclerosis; leaves open any clinical relevance pending human data.
Does insulin deficiency or treatment affect lipoprotein lipase secretion by murine macrophages?
Insulin deficiency indirectly causes a profound decrease in macrophage LPL secretion, which may contribute to the atherosclerotic process in diabetes mellitus.
Behr et al. (1988) studied Insulin deficiency. Insulin deficiency and insulin treatment vs. Control mice was evaluated on Lipoprotein lipase (LPL) secretion by murine macrophages. Insulin deficiency caused a 70% decrease in lipoprotein lipase secretion by murine macrophages, which was partially reversed by insulin treatment.
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