Key result
Diabetic rats had total LPL reduced by nearly two-thirds and less frequent ketonuria than starved rats (P<0.018), with severe hypertriglyceridemia occurring only in heavily ketonuric animals.
Population
Control and streptozocin-induced diabetic rats fed fat-free chow and 48-h-starved animals
Comparison
Streptozocin-induced diabetes or 48-h starvation vs Control rats
Design
Preclinical
Authors
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Hypothesis-generating in diabetic rats; leaves open translation to human dyslipidemia management.
p-value: p=<0.018
In a rat model of diabetes, total lipoprotein lipase activity is markedly reduced, and severe hypertriglyceridemia is associated with heavy ketonuria.
Wilson et al. (1987) studied Diabetes and starvation. Streptozocin-induced diabetes vs. Control and starved rats was evaluated on Ketonuria frequency (p=<0.018). Diabetic rats had total LPL reduced by nearly two-thirds and less frequent ketonuria than starved rats (P<0.018), with severe hypertriglyceridemia occurring only in heavily ketonuric animals.
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