Key result
Acute diabetes fails to reduce cardiac lipoprotein lipase activity in Wistar-Kyoto rats unlike Sprague-Dawley rats.
Why the study?
The mechanisms regulating myocardial lipoprotein lipase activity in acute diabetes and differences between rat strains were unclear.
Population
Wistar-Kyoto and Sprague-Dawley rats with streptozotocin-induced acute diabetes
Comparison
Diabetic Wistar-Kyoto rats vs diabetic Sprague-Dawley rats
Design
Preclinical experimental study
Follow-up
3-5 days
Authors
Loading...
Strain differences suggest LPL reduction may be compensatory rather than direct; leaves open human relevance.
The diabetes-induced reduction in myocardial lipoprotein lipase activity may be a compensatory response to hypertriglyceridemia and increased fatty acid delivery rather than a direct effect of diabetes itself.
Rodrigues et al. (1993) studied Acute diabetes. Streptozotocin-induced acute diabetes vs. Sprague-Dawley rats was evaluated on Heparin-releasable lipoprotein lipase activity in perfused hearts. Induction of acute diabetes in Wistar-Kyoto rats did not reduce heparin-releasable lipoprotein lipase activity in perfused hearts, unlike the reduction observed in Sprague-Dawley rats.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: