Why the study?
Does experimental diabetes alter the resistance of isolated rat hearts to in vitro ischemia and reperfusion injury?
Population
Isolated perfused rat hearts from control and diabetic animals (induced by streptozotocin or alloxan)
Comparison
Whole heart ischemia followed by reperfusion vs Isolated perfused hearts from normal rats…
Design
Preclinical
Authors
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Diabetic rat hearts show ischemia resistance; hypothesis-generating for Ca2+-mediated protection, requiring human validation before clinical consideration.
Does experimental diabetes alter the resistance of isolated rat hearts to in vitro ischemia and reperfusion injury?
Diabetic rat hearts demonstrate greater resistance to in vitro ischemia, which appears to be mediated by altered sarcolemmal Ca2+ transport systems that reduce damaging reperfusion Ca2+ influx.
Tani et al. (1988) studied this question.
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