Population
Alloxan diabetic rats, control rats, and reserpine-treated rats
Comparison
Intra-arterial injection of epinephrine… vs Control rats
Design
Preclinical
Authors
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Suggests a non-neuropathic mechanism of vascular hyperreactivity in diabetes; hypothesis-generating and requires human validation.
Experimental diabetes in rats enhances vascular reactivity to catecholamines and angiotensin, which does not appear to result from sympathetic neuropathy.
Brody et al. (1964) studied this question.
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