Key result
Daily insulin treatment in rats with STZ-induced diabetes completely prevented and reversed the increases in responsiveness of aortae and mesenteric arteries to norepinephrine.
Why the study?
Does insulin treatment prevent or reverse changes in vascular reactivity in rats with chronic experimental diabetes?
Population
Rats with chronic streptozocin (STZ)-induced diabetes
Comparison
Daily injections of insulin for 90 days or for… vs Untreated diabetic rats and age-matched…
Design
Preclinical
Follow-up
Up to 120 days
Authors
Loading...
Normalizes vascular reactivity in diabetic rat arteries; leaves open translation to human diabetes management.
Does insulin treatment prevent or reverse changes in vascular reactivity in rats with chronic experimental diabetes?
Insulin treatment prevents and reverses increased vascular reactivity to norepinephrine in chronic experimental diabetes, suggesting the reactivity is a consequence of the diabetic state.
Kathleen M. MacLeod (1985) studied STZ-induced diabetes. Insulin treatment vs. Untreated diabetic rats and nondiabetic controls was evaluated on Responsiveness of aortae and mesenteric arteries to norepinephrine. Daily insulin treatment in rats with STZ-induced diabetes completely prevented and reversed the increases in responsiveness of aortae and mesenteric arteries to norepinephrine.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: