Key result
Insulin treatment in diabetic rats significantly reduced vascular sensitivity to noradrenaline compared with both diet-restricted and untreated diabetic vessels (P<0.0001).
Why the study?
Does insulin treatment or food restriction alter vascular reactivity to noradrenaline and neuropeptide Y in streptozotocin-induced diabetic rats?
Does insulin treatment or food restriction alter vascular reactivity to noradrenaline and neuropeptide Y in streptozotocin-induced diabetic rats?
p-value: p=<0.0001
Insulin treatment, but not food restriction, reduces vascular sensitivity to noradrenaline in diabetic rats, supporting the hypothesis that insulin acts as a vasodilator.
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Animal data on diabetic vascular reactivity warrant no clinical change; leaves open mechanisms and human relevance.
Savage et al. (1995) studied Streptozotocin-induced diabetes (n=36). Insulin treatment or food restriction vs. Untreated diabetic rats and non-diabetic controls was evaluated on Contractile responses to noradrenaline without and with neuropeptide Y (p=<0.0001). Insulin treatment in diabetic rats significantly reduced vascular sensitivity to noradrenaline compared with both diet-restricted and untreated diabetic vessels (P<0.0001).
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