Why the study?
How does short-term alloxan-induced diabetes affect the renin-angiotensin system and catecholamine responsiveness in rats?
Population
Short term alloxan diabetic rats and streptozotocin-treated diabetic rats
Design
Preclinical
Follow-up
short term
Authors
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Hypothesizes diabetes-linked RAS suppression in rats; leaves open relevance to human diabetic complications.
How does short-term alloxan-induced diabetes affect the renin-angiotensin system and catecholamine responsiveness in rats?
In acutely diabetic alloxan-treated rats, the renin-angiotensin system is suppressed in proportion to diabetes severity, while norepinephrine responsiveness remains normal.
A.Richard Christlieb (1974) studied this question.
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