What question did this study set out to answer?

To investigate whether diabetes mellitus enhances systemic and renal vascular sensitivity to angiotensin I and angiotensin II.

September 1, 1996AJP Renal Physiology

Enhanced renal sensitivity to angiotensin actions in diabetes mellitus in the rat

View Full Paper

Ask AI

Bookmark

Why the study?

Does angiotensin administration alter renal hemodynamics differently in diabetic versus control rats?

Population

Control and diabetic rats

Comparison

Intravenous and intra-arterial angiotensin I and… vs Control (non-diabetic) rats

Design

Preclinical

Authors

TKThomas M. KennefickOregon Health & Science University TOT. T. OyamaOregon Health & Science University MTM. M. ThompsonOregon Health & Science University

Discussion

Member takes

Implication

May contribute to diabetic nephropathy pathogenesis; hypothesis-generating in animals and requires human validation.

Key Points

To investigate whether diabetes mellitus enhances systemic and renal vascular sensitivity to angiotensin I and angiotensin II.
Measured mean arterial pressure, glomerular filtration rate, and renal plasma flow in control and diabetic rats following intravenous administration of angiotensin I and II.
Infused identical doses of angiotensin I directly into the left renal artery to assess hemodynamic responses in treated and untreated kidneys without systemic pressure changes.
Intravenous infusions of angiotensin I and II produced equivalent increases in mean arterial pressure between groups, but renal plasma flow declined substantially more in diabetic rats.
Intra-arterial angiotensin I did not change mean arterial pressure in either group, yet elicited heightened renal hemodynamic responsiveness in both the infused and contralateral kidneys of diabetic rats.

Structured PICO

Does angiotensin administration alter renal hemodynamics differently in diabetic versus control rats?

Population

Control and diabetic rats

Intervention

Intravenous and intra-arterial angiotensin (ANG) I and ANG II

Comparator

Control (non-diabetic) rats

Outcome

Mean arterial pressure (MAP) and renal hemodynamics (glomerular filtration rate, renal plasma flow)surrogate

Diabetic rats exhibit enhanced renal, but not systemic, hemodynamic responsiveness to angiotensins, which may contribute to the pathogenesis of diabetic nephropathy.

Cite This Study

Kennefick et al. (1996) studied this question.

synapsesocial.com/papers/6a89a8f7b4e829b19bd45877 https://doi.org/10.1152/ajprenal.1996.271.3.f595

View Full Paper

Ask AI

Bookmark

Enhanced renal sensitivity to angiotensin actions in diabetes mellitus in the rat

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Enhanced renal sensitivity to angiotensin actions in diabetes mellitus in the rat

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider