Why the study?
Does glycaemic control affect the plasma angiotensin II and glomerular AII receptor relationship in diabetic hypertensive and normotensive rats?
Population
Spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats
Comparison
Streptozotocin 60 mg/kg to induce diabetes, with… vs Non-diabetic SHR and WKY rats
Design
Preclinical
Follow-up
7 days
Authors
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Hypertension may disrupt glomerular AII-AII-R regulation in diabetic rats independently of glycemic control; leaves open relevance to human diabetic nephropathy.
Does glycaemic control affect the plasma angiotensin II and glomerular AII receptor relationship in diabetic hypertensive and normotensive rats?
The absence of a normal inverse relationship between plasma angiotensin II and its glomerular receptor in diabetic hypertensive rats is not reversed by glycemic control, suggesting hypertension directly influences renal function in this model.
MAKARIOUS et al. (1993) studied this question.
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