Population
Streptozotocin-diabetic rats and age-matched control rats
Comparison
Intravenous injection of streptozotocin to… vs Age-matched control rats
Design
Preclinical
Follow-up
8 weeks
Authors
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Hypothesis-generating for biphasic RAAS changes in diabetes; should not alter clinical practice without human validation.
Diabetes induced by streptozotocin in rats causes a biphasic alteration of the renin-angiotensin-aldosterone system, characterized by early stimulation and later suppression.
Kikkawa et al. (1986) studied this question.
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