Key result
Streptozotocin-induced diabetes in rats caused tissue-specific and time-dependent changes in angiotensin II receptors, with increases in the heart, liver, and adrenal glands, and decreases in the kidneys.
Why the study?
Does streptozotocin-induced diabetes alter angiotensin II receptor density in a tissue-specific manner in rats?
Does streptozotocin-induced diabetes alter angiotensin II receptor density in a tissue-specific manner in rats?
STZ-induced diabetes in rats causes major, tissue-specific, and time-dependent changes in angiotensin II receptor density, including significant increases in the left ventricle and decreases in the kidney.
No takes yet. Share an insight, caveat, or question.
No immediate clinical implications; leaves open whether tissue-specific angiotensin II receptor changes translate to human diabetes.
Brown et al. (1997) studied Streptozotocin-induced diabetes. Streptozotocin (STZ) treatment vs. Non-diabetic controls was evaluated on Tissue-specific changes in angiotensin II (AT) receptors. Streptozotocin-induced diabetes in rats caused tissue-specific and time-dependent changes in angiotensin II receptors, with increases in the heart, liver, and adrenal glands, and decreases in the kidneys.
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