Key result
Streptozotocin-induced early stage Type 1 diabetes in rats increased plasma AngII (152 vs 101 fmol/ml) and elevated renal cortical AT1 receptor protein levels by 77-101% compared to sham rats.
Why the study?
Does early-stage Type 1 diabetes mellitus induced by STZ increase renal angiotensin II concentration and AT1 receptor protein levels in rats?
Does early-stage Type 1 diabetes mellitus induced by STZ increase renal angiotensin II concentration and AT1 receptor protein levels in rats?
Early-stage Type 1 diabetes in rats increases circulating AngII and renal cortical AT1 receptor protein expression, suggesting an exaggerated AngII-dependent influence on renal function.
Answers are grounded in this paper and cite their sources.
Should not change T1DM management; hypothesis-generating for AngII/AT1 upregulation in early diabetic nephropathy.
Experiments were performed to evaluate the hypothesis that the early stage of Type 1 diabetes mellitus (DM) increases renal angiotensin II (AngII) concentration and angiotensin type 1 (AT) receptor protein levels. Nineteen or twenty days after vehicle (Sham rats) or streptozotocin (STZ rats) treatment, plasma [AngII] was higher in STZ rats (152 +/- 23 fmol/ml) than in Sham rats (101 +/- 7 fmol/ml); however, kidney [AngII] did not differ between groups. AT1 receptor protein expression was greater in STZ kidneys than in Sham kidneys. This increase was restricted to the cortex, where AT1 protein levels were elevated by 77 +/- 26% (42 kDa) and 101 +/- 16% (58 kDa) in STZ kidneys. Immunohistochemistry revealed this effect to be most evident in distal nephron segments including the connecting tubule/cortical collecting duct. Increased renal cortical AT1 receptor protein and circulating AngII levels are consistent with an exaggerated AngII-dependent influence on renal function during the early stage of DM in the rat.
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Harrison‐Bernard et al. (2001) studied Type 1 diabetes mellitus. Streptozotocin (STZ) treatment vs. Vehicle (Sham rats) was evaluated on Plasma Angiotensin II concentration (fmol/ml). Streptozotocin-induced early stage Type 1 diabetes in rats increased plasma AngII (152 vs 101 fmol/ml) and elevated renal cortical AT1 receptor protein levels by 77-101% compared to sham rats.
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