Why the study?
Does PD-123319 alter renal sodium excretion in streptozotocin-induced diabetic rats?
Population
Streptozotocin (STZ)-induced diabetic rats and non-diabetic control rats
Comparison
Infusion of PD-123319 (an AT2 receptor antagonist) vs Control rats receiving the same infusion, and…
Design
Preclinical
Authors
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Extends evidence for AT2-mediated natriuresis in experimental diabetes; leaves open translation to human diabetic kidney disease.
Does PD-123319 alter renal sodium excretion in streptozotocin-induced diabetic rats?
AT2 receptor antagonism decreases sodium excretion in diabetic rats, suggesting that enhanced tubular AT2 receptor expression promotes natriuresis via a cGMP pathway in diabetes.
Hakam et al. (2005) studied this question.
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