Key result
Streptozotocin-induced diabetes progressively increased the expression of angiotensin II type 1 receptors in rat bladder smooth muscle cell membranes at 2 and 8 weeks compared to controls.
Continuous hyperglycemia caused by streptozotocin administration may activate the local renin-angiotensin system in the rat bladder, evidenced by increased AT1 receptor expression.
Answers are grounded in this paper and cite their sources.
Does not yet inform clinical management of diabetic bladder dysfunction; leaves open the role of AT1 upregulation in human disease.
INTRODUCTION: The aim of this study was to investigate angiotensin II type 1 (AT1) receptors in rat bladder smooth muscle cells and alterations of AT1 receptors by diabetes mellitus and diuretic states. MATERIALS AND METHODS: Diabetes and diuresis were induced in adult female rats by a single intraperitoneal injection of streptozotocin and feeding 5% sucrose in water. Cystometry was performed on control, diuretic, and diabetic rats at 2 and 8 weeks after treatment. Immunohistochemical staining was used to detect expression of AT1 receptors in the bladder smooth muscle cell membrane. RESULTS AND CONCLUSIONS: In diabetic rats, expression of AT1 receptors in the bladder smooth muscle cell membrane increased at 2 weeks and further increased at 8 weeks. The local renin-angiotensin system in the rat bladder might be activated by the continuous hyperglycemia caused by intraperitoneal injection of streptozotocin administration.
No takes yet. Share an insight, caveat, or question.
Tobu et al. (2012) studied Diabetic cystopathy (n=35). Streptozotocin-induced diabetes vs. Normal control rats and sucrose-induced diuretic rats was evaluated on Expression of angiotensin II type 1 (AT1) receptors in bladder smooth muscle cell membrane. Streptozotocin-induced diabetes progressively increased the expression of angiotensin II type 1 receptors in rat bladder smooth muscle cell membranes at 2 and 8 weeks compared to controls.
Synapse has enriched 10 related papers. Consider them for comparative context: