Why the study?
Does STZ-induced diabetes alter the cardiac renin-angiotensin system in Sprague-Dawley rats?
Population
Sprague-Dawley rats
Comparison
Streptozotocin-induced diabetes vs Vehicle-treated control rats and…
Design
Preclinical
Follow-up
14 days
Authors
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May indicate local cardiac RAS activation in hyperglycemic diabetes; leaves open translation to human cardiomyopathy.
Does STZ-induced diabetes alter the cardiac renin-angiotensin system in Sprague-Dawley rats?
STZ-induced diabetes increases myocardial angiotensin II receptor density and AT1 receptor mRNA levels in rats, independent of changes in the circulating renin-angiotensin system.
Sechi et al. (1994) studied this question.
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