Key result
Angiotensin II administration amplified the increase in left ventricular ANP and BNP mRNA levels in diabetic rats compared to controls (e.g., 11-fold increase in ANP mRNA at 2.5 weeks, P<0.001).
Why the study?
Does angiotensin II alter the expression of natriuretic peptide genes in the left ventricle of streptozotocin-induced diabetic rats?
Population
Male Wistar rats with streptozotocin (STZ; 60 mg/kg IV)-induced diabetes or vehicle control
Comparison
Angiotensin II administered via osmotic… vs Vehicle in both diabetic and non-diabetic…
Design
Preclinical
Follow-up
2.5 or 7 weeks
Authors
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May indicate amplified natriuretic peptide response to angiotensin II in diabetic myocardium; hypothesis-generating, should not yet inform practice.
Does angiotensin II alter the expression of natriuretic peptide genes in the left ventricle of streptozotocin-induced diabetic rats?
p-value: p=<0.001
Angiotensin II induces an amplified response in the expression of ANP and BNP genes in the left ventricle of diabetic rats compared to non-diabetic controls.
Ruzicska et al. (2004) studied Streptozotocin-induced diabetes. Angiotensin II vs. Vehicle / control animals was evaluated on Levels of ANP, BNP, and adrenomedullin mRNA in the left ventricle (p=<0.001). Angiotensin II administration amplified the increase in left ventricular ANP and BNP mRNA levels in diabetic rats compared to controls (e.g., 11-fold increase in ANP mRNA at 2.5 weeks, P<0.001).
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