Why the study?
Does streptozotocin-induced diabetes alter atrial natriuretic peptide gene expression and hemodynamics in WKY and SHR rats, and are these effects reversible with insulin therapy?
Population
Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHRs)
Comparison
Streptozotocin-induced diabetes, with subsequent… vs Age-matched non-diabetic WKY rats and SHRs
Design
Preclinical
Follow-up
Up to 12 weeks
Authors
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Animal findings of reversible ANP upregulation in diabetic rats should not change practice; hypothesis-generating for human diabetic cardiomyopathy mechanisms.
Does streptozotocin-induced diabetes alter atrial natriuretic peptide gene expression and hemodynamics in WKY and SHR rats, and are these effects reversible with insulin therapy?
Diabetes augments cardiac ANP synthesis and elevates intraventricular filling pressures prior to observable cardiomyopathic changes, effects that are exacerbated by concurrent hypertension and reversible with insulin therapy.
Matsubara et al. (1990) studied this question.
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