Key result
Streptozotocin-induced diabetes in rats doubled vascular ACE activity at 2 weeks compared to controls (0.46 vs 0.19 nmol/mg x min, p<0.05), alongside impaired endothelial function and increased blood pressure.
Population
Streptozotocin-diabetic Sprague-Dawley rats
Comparison
Induction of diabetes (evaluated at 2 and 4 weeks) vs Age-matched non-diabetic Sprague-Dawley rats
Design
Preclinical
Follow-up
4 weeks
Authors
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Associates early vascular ACE upregulation with diabetic dysfunction in rats; hypothesis-generating and leaves open human relevance.
Absolute Event Rate: 0.46% vs 0.19%
p-value: p=<0.05
In a rat model of diabetes, early cardiovascular deterioration and vascular dysfunction are associated with a transient increase in local vascular ACE activity.
Crespo et al. (2003) studied Streptozotocin-induced diabetes. Streptozotocin-induced diabetes vs. Age-matched Sprague-Dawley control rats was evaluated on Vascular ACE activity at 2 weeks (nmol/mg x min) (p=<0.05). Streptozotocin-induced diabetes in rats doubled vascular ACE activity at 2 weeks compared to controls (0.46 vs 0.19 nmol/mg x min, p<0.05), alongside impaired endothelial function and increased blood pressure.
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