Why the study?
Does streptozotocin-induced diabetes impair autonomic regulation of heart rate and endothelial function in Sprague-Dawley rats?
Population
Weanling Sprague-Dawley rats (3-4 weeks of age) of either sex, n=20
Comparison
Single intraperitoneal injection of… vs Intraperitoneal (IP) injection of saline
Design
Preclinical, Randomly assigned
Follow-up
8 weeks
Authors
Loading...
These rat data do not inform clinical practice; they extend preclinical evidence of autonomic impairment but leave human relevance open.
Does streptozotocin-induced diabetes impair autonomic regulation of heart rate and endothelial function in Sprague-Dawley rats?
Streptozotocin-induced diabetes in rats leads to impaired autonomic control of heart rate and endothelial dysfunction after 8 weeks.
Martínez‐Nieves et al. (2000) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: