Population
Male Wistar rats (N=18; 9 control, 9 diabetic)
Comparison
Streptozotocin 50 mg/kg i.v. to induce diabetes… vs Control rats
Design
Preclinical
Follow-up
15 days
Authors
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Caution against extrapolating to diabetic patients; hypothesis-generating for autonomic reflex impairment, needs clinical confirmation.
STZ-induced diabetes in rats impairs cardiovascular responses evoked by baroreflex and chemoreflex activation, likely secondary to autonomic dysfunction.
Fernandes et al. (1997) studied this question.
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