Key result
Chronic vitamin E treatment prevented the impairment of cardiac chemoreflexes and afferent discharge to chemical stimulation in STZ-induced diabetic rats.
Why the study?
Does vitamin E prevent the impairment of cardiac chemoreflexes in STZ-induced diabetic rats?
Population
Rats with streptozotocin (STZ; 85 mg/kg ip)-induced diabetes
Comparison
Vitamin E vs Sham-treated rats, STZ-treated rats without…
Design
Preclinical
Follow-up
6-8 weeks
Authors
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Supports oxidative stress mediation of diabetic cardiac neuropathy in rats; leaves open translation to human therapy.
Does vitamin E prevent the impairment of cardiac chemoreflexes in STZ-induced diabetic rats?
p-value: p=< 0.05
Chronic vitamin E treatment prevents the impairment of cardiac chemosensitive nerve endings in STZ-induced diabetic rats, suggesting oxidative stress mediates this autonomic neuropathy.
Ustinova et al. (2000) studied Diabetes mellitus. Vitamin E vs. Sham treatment or STZ without vitamin E was evaluated on Reflex depression or elevation of renal sympathetic nerve activity (RSNA) and mean arterial blood pressure (MABP) in response to capsaicin and bradykinin (p=< 0.05). Chronic vitamin E treatment prevented the impairment of cardiac chemoreflexes and afferent discharge to chemical stimulation in STZ-induced diabetic rats.
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