Key result
Experimental diabetes in rats abolished the reflex reduction of renal sympathetic nerve activity in response to acute volume expansion (1.9% vs -14%/mm Hg in controls).
Why the study?
Does experimental diabetes impair cardiopulmonary reflex control of circulation in rats?
Population
Rats with experimental diabetes induced by streptozotocin
Comparison
Administration of increasing doses of serotonin… vs Normal control rats
Design
Preclinical
Authors
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Hypothesis-generating for cardiopulmonary receptor changes in diabetic rats; human relevance remains to be tested.
Does experimental diabetes impair cardiopulmonary reflex control of circulation in rats?
Absolute Event Rate: 1.9% vs -14%
Experimental diabetes in rats abolishes the cardiopulmonary reflex control of circulation during acute volume expansion, while responses to serotonin remain preserved.
Oliveira et al. (1999) studied Experimental diabetes. Experimental diabetes vs. Normal control rats was evaluated on Reflex reduction of renal sympathetic nerve activity in response to increasing left end-diastolic pressure. Experimental diabetes in rats abolished the reflex reduction of renal sympathetic nerve activity in response to acute volume expansion (1.9% vs -14%/mm Hg in controls).
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