What question did this study set out to answer?

To determine the effect of chronic diabetes mellitus on arterial baroreflex control of heart rate in conscious rabbits.

January 1, 1994AJP Heart and Circulatory Physiology

Baroreflex dysfunction in diabetes mellitus. I. Selective impairment of parasympathetic control of heart rate

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Why the study?

Does diabetes mellitus impair baroreflex control of heart rate in a rabbit model?

Population

Conscious rabbits

Comparison

Alloxan-induced diabetes mellitus vs Alloxan-treated normoglycemic rabbits and…

Design

Preclinical

Follow-up

24 weeks

Authors

TMT. McDowellUniversity of Iowa MCMark W. ChapleauGeneral Cardiology GHG. HajduczokBuffalo State University

Discussion

Member takes

Implication

Selective baroreflex bradycardia impairment in diabetic rabbits; leaves open translation to human autonomic neuropathy.

Key Points

To determine the effect of chronic diabetes mellitus on arterial baroreflex control of heart rate in conscious rabbits.
Diabetes was induced in rabbits with alloxan (n=9; blood glucose = 378 ± 21 mg/dl) and compared with alloxan-treated normoglycemic rabbits (n=9) and saline-treated controls (n=5).
Baroreflex curves were generated in conscious animals by infusing phenylephrine to raise arterial pressure and nitroglycerin to lower arterial pressure over a 24-week period.
Parasympathetic and sympathetic contributions were isolated using beta-adrenergic blockade with propranolol (1 mg/kg).
Baroreflex bradycardia gain in response to increased pressure decreased from -1.8 ± 0.3 beats·min⁻¹·mmHg⁻¹ at baseline (n=9) to -0.9 ± 0.1 at 12 weeks and -0.9 ± 0.3 beats·min⁻¹·mmHg⁻¹ at 24 weeks in diabetic rabbits (n=8; P < 0.05), while remaining unchanged in normoglycemic controls.
Impairment of baroreflex-mediated bradycardia persisted after beta-adrenergic blockade with propranolol in diabetic rabbits compared with controls.
Baroreflex-mediated tachycardia gain during arterial pressure reduction was not significantly altered by diabetes in either vagal or sympathetic components.

Structured PICO

Does diabetes mellitus impair baroreflex control of heart rate in a rabbit model?

Population

Conscious rabbits (n=23 total: 9 with alloxan-induced diabetes, 9 alloxan-treated normoglycemic controls, 5 saline-treated controls)

Intervention

Alloxan-induced diabetes mellitus

Comparator

Alloxan-treated normoglycemic rabbits and saline-treated rabbits

Outcome

Baroreflex control of heart rate (gain of baroreflex-mediated bradycardia and tachycardia in response to changes in arterial pressure)surrogate

Diabetes mellitus selectively impairs the parasympathetic component of baroreflex-mediated bradycardia in a rabbit model.

Cite This Study

McDowell et al. (1994) studied this question.

synapsesocial.com/papers/6a84f7aed66f5a06605b5cb6 https://doi.org/10.1152/ajpheart.1994.266.1.h235

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Baroreflex dysfunction in diabetes mellitus. I. Selective impairment of parasympathetic control of heart rate

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Baroreflex dysfunction in diabetes mellitus. I. Selective impairment of parasympathetic control of heart rate

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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