Population
13 male Wistar rats (6 control, 7 diabetic)
Comparison
Streptozotocin 65 mg IP to induce diabetes for 5… vs Control group (non-diabetic rats)
Design
Preclinical
Follow-up
5 days
Authors
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Rat autonomic changes in diabetes should not alter practice; leaves open translation to human cardiac control.
Short-term experimental diabetes in rats induces early autonomic dysfunction, characterized by depressed vagal and sympathetic tone and reduced intrinsic heart rate.
Maeda et al. (1995) studied this question.
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