Why the study?
Does insulin treatment modify heart rate and blood pressure variability in streptozotocin-induced diabetic rats?
Population
Rats (164.5 +/- 1.7 g) with streptozotocin (STZ)-induced diabetes
Comparison
Insulin treatment vs Control rats
Design
Preclinical
Follow-up
120 days
Authors
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Transient HR/HRV shifts in early STZ-diabetes are reversible in rats; leaves open insulin's long-term effects on autonomic control.
Does insulin treatment modify heart rate and blood pressure variability in streptozotocin-induced diabetic rats?
Short-term diabetes mellitus induced by STZ in rats causes reversible modifications in autonomic control of heart rate and mean arterial pressure, which may be influenced by insulin treatment and metabolic control.
Schaan et al. (1997) studied this question.
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