What is the clinical evidence from this study?

Study design: Other. Population: Diabetes. Intervention: Angiotensin II vs. Nondiabetic mice. Primary outcome: Mean arterial pressure (MAP) in response to acute bolus intravenous injection of ANG II.

What question did this study set out to answer?

To determine whether enhanced constriction of renal afferent arterioles mediated by AT1 receptors drives the heightened susceptibility to hypertension in diabetes.

August 26, 2017Physiological GenomicsOpen Access

Enhanced hemodynamic responses to angiotensin II in diabetes are associated with increased expression and activity of AT1 receptors in the afferent arteriole

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Key result

Diabetic mice exhibited a higher mean arterial pressure (119.1 vs. 106.2 mmHg) in response to acute angiotensin II injection compared with nondiabetic mice.

Population

Alloxan-induced diabetic mice and nondiabetic mice

Comparison

Angiotensin II vs Nondiabetic mice receiving the same treatment

Design

Preclinical

Authors

JZJie ZhangHeilongjiang University of Chinese Medicine HQHelena Y. QuUniversity of South Florida JSJiangping SongCardiac Surgery

Discussion

Member takes

Implication

Provides mechanistic insight into the increased prevalence of hypertension in diabetes; leaves open whether targeting AT1 receptor.

Key Points

To determine whether enhanced constriction of renal afferent arterioles mediated by AT1 receptors drives the heightened susceptibility to hypertension in diabetes.
Evaluated acute mean arterial pressure and renal blood flow responses to intravenous bolus angiotensin II in alloxan-induced diabetic mice versus nondiabetic controls.
Tracked blood pressure changes via telemetry during chronic angiotensin II infusion and measured AT1 and AT2 receptor mRNA expression and contractile responses in isolated afferent arterioles.
Acute angiotensin II injection produced higher mean arterial pressure (119.1 ± 3.8 vs. 106.2 ± 3.5 mmHg) and lower renal blood flow (0.25 ± 0.07 vs. 0.52 ± 0.14 ml/min) in diabetic compared with nondiabetic mice.
Chronic angiotensin II infusion increased mean arterial pressure by 55.8 ± 6.5 mmHg in diabetic mice versus 32.3 ± 3.8 mmHg in nondiabetic controls.
Diabetic mice displayed a ~10-fold increase in afferent arteriole AT1 receptor mRNA expression without altering AT2 expression, accompanied by amplified vasoconstriction that was blocked by losartan.

Structured PICO

Population

Alloxan-induced diabetic mice and nondiabetic mice.

Intervention

Angiotensin II (acute bolus intravenous injection and chronic infusion)

Comparator

Nondiabetic mice receiving the same treatment

Outcome

Mean arterial pressure (MAP) and renal blood flowsurrogate

Main Result

Absolute Event Rate: 119.1% vs 106.2%

Enhanced expression of AT1 receptors and exaggerated hemodynamic responses to angiotensin II in the afferent arterioles of diabetic mice may explain the increased prevalence of hypertension in diabetes.

Cite This Study

Zhang et al. (2017) studied Diabetes. Angiotensin II vs. Nondiabetic mice was evaluated on Mean arterial pressure (MAP) in response to acute bolus intravenous injection of ANG II. Diabetic mice exhibited a higher mean arterial pressure (119.1 vs. 106.2 mmHg) in response to acute angiotensin II injection compared with nondiabetic mice.

synapsesocial.com/papers/6a89aa84ea82e62cf6fd4cbb https://doi.org/10.1152/physiolgenomics.00025.2017

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Enhanced hemodynamic responses to angiotensin II in diabetes are associated with increased expression and activity of AT1 receptors in the afferent arteriole

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Enhanced hemodynamic responses to angiotensin II in diabetes are associated with increased expression and activity of AT1 receptors in the afferent arteriole

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider