Why the study?
Does alloxan-induced diabetes increase sensitivity to ischemia-reperfusion injury in rabbit hearts?
Population
Rabbits with 8-16 weeks of alloxan-induced diabetes and normal rabbits
Comparison
Ischemia-reperfusion injury vs Normal rabbit hearts subjected to the same…
Design
Preclinical
Follow-up
24 hours (for reperfusion in ligation experiments)
Authors
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No increased ischemia-reperfusion sensitivity in alloxan-diabetic rabbit hearts; leaves open translation to human diabetic myocardium.
Does alloxan-induced diabetes increase sensitivity to ischemia-reperfusion injury in rabbit hearts?
Alloxan-induced diabetes in rabbits causes baseline mechanical abnormalities but does not increase the severity of myocardial injury following ischemia-reperfusion.
Vogel et al. (1988) studied this question.
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