Key result
Diabetes and hyperglycemia prevented normal microvascular dilation during coronary occlusion, causing arteriolar constriction (-15% and -8% diameter change) compared to dilation (+26%) in controls.
Why the study?
Does diabetes or hyperglycemia impair coronary microvascular dilatory responses to ischemia in a canine model?
Population
33 dogs, including 9 alloxan-treated (60 mg/kg i.v.) diabetic dogs, 8 hyperglycemic dogs, and 16 control dogs.
Comparison
Diabetes or hyperglycemia during graded… vs Normoglycemic control dogs undergoing the same…
Design
Preclinical
Authors
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Diabetes may worsen ischemic outcomes via microvascular constriction; leaves open translation to human coronary disease and therapies.
Does diabetes or hyperglycemia impair coronary microvascular dilatory responses to ischemia in a canine model?
Absolute Event Rate: -15% vs 26%
Diabetes and hyperglycemia impair the normal coronary microvascular dilatory response to ischemia in a canine model, potentially contributing to worse ischemic outcomes in diabetic patients.
Kersten et al. (1995) studied Diabetes and hyperglycemia (n=33). Diabetes and hyperglycemia vs. Control dogs was evaluated on Change in arteriolar microvessel (< 100 microns) diameter from baseline during coronary occlusion. Diabetes and hyperglycemia prevented normal microvascular dilation during coronary occlusion, causing arteriolar constriction (-15% and -8% diameter change) compared to dilation (+26%) in controls.
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