Why the study?
Does STZ-induced diabetes alter vasomotor reactivity in isolated coronary arteries of rats?
Population
Isolated intramyocardial arteries from Wistar rats 8 weeks after induction of diabetes mellitus by…
Comparison
Vasomotor agents vs Vessels from age- and weight-matched control rats
Design
Preclinical
Follow-up
8 weeks (after induction of diabetes)
Authors
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Impaired reactivity in STZ-diabetic rat coronaries warrants caution against clinical extrapolation; leaves open translation to human diabetic vasculopathy.
Does STZ-induced diabetes alter vasomotor reactivity in isolated coronary arteries of rats?
STZ-induced diabetes selectively modifies coronary circulation in rats, reducing contractile responses to prostaglandin F2 alpha and potassium and impairing relaxant responses to several agents.
Sjögren et al. (1988) studied this question.
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