Key result
Enhanced vascular smooth muscle myosin light-chain phosphorylation strongly correlated with impaired endothelium-independent vasodilation in diabetic coronary microvessels (r=0.670, P<0.01).
Why the study?
Does enhanced vascular smooth muscle MLC phosphorylation correlate with impaired endothelium-independent coronary microvascular dilation in diabetes?
Population
Yucatan miniswine with alloxan-induced type 1 diabetes and nondiabetic controls, as well as coronary…
Comparison
Sodium nitroprusside to assess… vs Nondiabetic controls and untreated diabetic swine.
Design
Preclinical
Authors
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Hypothesis-generating for MLC phosphorylation as target in diabetic microvascular dysfunction; human studies needed before clinical relevance.
Does enhanced vascular smooth muscle MLC phosphorylation correlate with impaired endothelium-independent coronary microvascular dilation in diabetes?
Effect estimate: r=0.670
p-value: p=<0.01
Impaired endothelium-independent coronary microvascular dilation in diabetes correlates with enhanced vascular smooth muscle myosin light-chain phosphorylation, providing a mechanistic explanation for diabetic vascular dysfunction.
Clements et al. (2009) studied Type 1 and Type 2 Diabetes. Insulin (in swine) / Sodium nitroprusside (ex vivo) vs. Nondiabetic controls was evaluated on Correlation between MLC phosphorylation and impaired VSM relaxation (r=0.670, p=<0.01). Enhanced vascular smooth muscle myosin light-chain phosphorylation strongly correlated with impaired endothelium-independent vasodilation in diabetic coronary microvessels (r=0.670, P<0.01).
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