Depressed modulation of oxygen consumption by endogenous nitric oxide in cardiac muscle from diabetic dogs

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Why the study?

Does diabetes impair the modulation of oxygen consumption by endogenous nitric oxide in canine cardiac muscle?

Structured PICO

Does diabetes impair the modulation of oxygen consumption by endogenous nitric oxide in canine cardiac muscle?

Population

Canine cardiac muscle slices and coronary microvessels from dogs with alloxan-induced diabetes (40-60 mg/kg iv, 4-5 weeks duration) and normal dogs

Intervention

Endogenous NO stimulators (bradykinin, carbachol, kininogen, kallikrein, ACh) and exogenous NO donor (S-nitroso-N-acetylpenicillamine)

Comparator

Normal (non-diabetic) canine cardiac muscle and microvessels

Outcome

Modulation of oxygen consumption by nitric oxidesurrogate

Diabetes impairs the modulation of myocardial oxygen consumption by endogenous nitric oxide, likely due to decreased endothelial NO release.

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Impaired NO modulation of myocardial O2 consumption in diabetic canine tissue should not change practice; leaves open human relevance and mechanisms.

Zhao et al. (2000) studied this question.

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Impaired NO modulation of myocardial O2 consumption in diabetic canine tissue should not change practice; leaves open human relevance and mechanisms.