Why the study?
Does the use of simultaneous T-1824 and tritiated water dilution curves reliably quantify pulmonary edema compared to clinical criteria in anesthetized dogs?
Population
Intact, anesthetized dogs with experimentally induced pulmonary engorgement
Comparison
Determination of pulmonary blood volume and… vs Clinical criteria and mechanics of breathing
Design
Preclinical
Authors
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Provides validated experimental quantification of pulmonary edema in dogs; leaves open translation to clinical use.
Does the use of simultaneous T-1824 and tritiated water dilution curves reliably quantify pulmonary edema compared to clinical criteria in anesthetized dogs?
Simultaneous T-1824 and tritiated water dilution curves provide a reliable quantitative method for detecting and measuring pulmonary edema, outperforming standard clinical criteria in a canine model.
Levine et al. (1965) studied this question.
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