Why the study?
Does pulmonary extravascular fluid volume measured by a double isotope technique correlate with clinical severity and hemodynamic parameters in patients with valvular heart disease?
Population
54 subjects, comprising 9 normal subjects and 45 patients with valvular heart disease.
Comparison
Measurement of pulmonary extravascular fluid… vs Normal subjects
Design
Cross-sectional
Authors
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May support earlier congestion detection in valve disease; hypothesis-generating for outcome impact and prospective validation.
Does pulmonary extravascular fluid volume measured by a double isotope technique correlate with clinical severity and hemodynamic parameters in patients with valvular heart disease?
Measurement of pulmonary extravascular fluid volume using a double isotope technique correlates with left atrial pressure and dyspnea severity in valvular heart disease, often detecting edema before radiological evidence is present.
Michael McCredie (1967) studied this question.