What question did this study set out to answer?

To synthesize anatomical and physiological mechanisms governing pulmonary fluid balance and explain the pathogenesis of diverse clinical forms of pulmonary edema.

August 1, 1972CirculationOpen Access

Pulmonary Edema

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Authors

AFAlfred P. FishmanTulane University

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Implication

Pathophysiological review demonstrates how fluid extravasation overwhelms lymphatic clearance in pulmonary edema, highlighting anatomic limitations across diverse clinical etiologies.

Key Points

To synthesize anatomical and physiological mechanisms governing pulmonary fluid balance and explain the pathogenesis of diverse clinical forms of pulmonary edema.
Analyzed microvascular fluid filtration and lymphatic clearance dynamics across interstitial, alveolar, and airway compartments.
Applied physiological fluid principles to specific clinical entities, including post-resuscitative shock lung, high-altitude exposure, and narcotic overdoses.
Identified that pulmonary edema manifests when fluid filtration into extravascular spaces exceeds the maximal clearance capacity of narrow thoracic lymphatic drainage pathways.
Determined that post-hypotension shock lung arises primarily from nonuniform pulmonary hypoperfusion during recovery, whereas high-altitude edema is driven by regional variations in precapillary resistance.
Attributed narcotic-induced edema to a combination of hypoxemia, respiratory acidosis, left ventricular dysfunction, impaired lymphatic return, and contaminant-induced microvascular leakage.

Cite This Study

Alfred P. Fishman (1972) studied this question.

synapsesocial.com/papers/6a192cf2a0353395e957f5f8 https://doi.org/10.1161/01.cir.46.2.390

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Implication

Pathophysiological review demonstrates how fluid extravasation overwhelms lymphatic clearance in pulmonary edema, highlighting anatomic limitations across diverse clinical etiologies.

Pulmonary Edema

Discussion

Member takes

Implication

Key Points

Cite This Study

Pulmonary Edema

Discussion

Member takes

Implication

Key Points

Cite This Study

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