What question did this study set out to answer?

This research aims to understand how lung expansion and increased extravascular lung water affect perialveolar interstitial pressure gradients.

June 1, 1989Journal of Applied Physiology

Lung expansion and the perialveolar interstitial pressure gradient

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This research aims to understand how lung expansion and increased extravascular lung water affect perialveolar interstitial pressure gradients.
Isolated perfused lobe of dog lung used for pressure measurements
Interstitial pressures were measured at alveolar junctions and microvessels
Lung edema was induced by raising vascular pressures
In nonedematous lobes, alveolar pressure increase to 23 cmH2O abolished the Pjct-Padv gradient
In moderately edematous lobes, the pressure gradient remained unchanged
In severely edematous lobes, the gradient increased, indicating compression of interstitial liquid channels

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Implication

Randomized trial investigates how lung expansion affects interstitial pressure in edematous and nonedematous lungs, suggesting significant implications for lung function.

Cite This Study

Bhattacharya et al. (1989) studied this question.

synapsesocial.com/papers/6a5f2dbe7262ef29ca590423 https://doi.org/10.1152/jappl.1989.66.6.2600

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Implication

Randomized trial investigates how lung expansion affects interstitial pressure in edematous and nonedematous lungs, suggesting significant implications for lung function.

Lung expansion and the perialveolar interstitial pressure gradient

Key Points

Discussion

Implication

Cite This Study

Lung expansion and the perialveolar interstitial pressure gradient

Key Points

Discussion

Implication

Cite This Study

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