Why the study?
Does increasing transpulmonary pressure affect the rate of pulmonary edema formation in isolated canine lungs?
Population
Isolated canine left lower lobes
Comparison
Increasing transpulmonary pressure (Ptp) vs Different constant vascular pressures
Design
Preclinical
Authors
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May caution against assuming uniform effects of transpulmonary pressure on edema; leaves open translation from isolated lungs to clinical practice.
Does increasing transpulmonary pressure affect the rate of pulmonary edema formation in isolated canine lungs?
In an isolated canine lung model, the effect of transpulmonary pressure on pulmonary edema formation depends on whether vascular bed derecruitment occurs.
Goldberg et al. (1977) studied this question.
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