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February 1, 1997Circulation Research

Tissue and Species Distribution of mRNA for the ikr-like K+Channel, ERG

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Population

cDNA fragments of erg homologues from guinea pig, rabbit, human, dog, and rat; isolated rat ventricular…

Design

Preclinical

Key result

erg mRNA is uniformly expressed in the hearts of multiple species and correlates with the presence of an E-4031-sensitive IKr-like current in rat ventricular myocytes.

Authors

RWRandy S. WymoreGGGary A. GintantRWRigel T. Wymore

Discussion

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Overview

Supports erg-IKr molecular link across species; leaves open clinical translation to human arrhythmias.

Structured PICO

P
Population
cDNA fragments of erg homologues from guinea pig, rabbit, human, dog, and rat; isolated rat ventricular myocytes
E
Exposure
RNase protection assays and electrophysiological studies
O
Outcome
Presence and distribution of erg mRNA in cardiac and noncardiac tissues, and presence of IKr-like current in rat heartsurrogate

The study demonstrates that erg mRNA is widely expressed in the hearts of multiple species and correlates with the presence of an IKr-like current, strengthening the link between erg and native IKr.

Cite This Study

Wymore et al. (1997) studied this question. erg mRNA expression was evaluated on Presence and distribution of erg mRNA and IKr-like current. erg mRNA is uniformly expressed in the hearts of multiple species and correlates with the presence of an E-4031-sensitive IKr-like current in rat ventricular myocytes.

synapsesocial.com/papers/6a222a553081c2f8f8e24c86https://doi.org/10.1161/01.res.80.2.261
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