A review of the renin-angiotensin-aldosterone system suggests that local synthesis of angiotensin peptides, particularly in the brain, may contribute to the development of hypertensive disease.
Angiotensin II has long been recognized as a key factor in cardiovascular regulation. The effectiveness of angiotensin-converting enzyme (ACE) inhibitors in controlling essential hypertension suggests that angiotensin II plays a key role in its pathology. The tools of molecular biology have provided the means for a critical reassessment of the renin-angiotensin-aldosterone system in physiology and pathology. The analysis has shown that angiotensin peptides are also synthesized and processed locally in a variety of tissues, including the vascular wall, adrenal glands, heart, and brain. Since angiotensin II is a potent modulator of cardiovascular control centers in the brain, the hypothesis is now advanced that a defect in the brain renin-angiotensin-aldosterone system contributes to the development of hypertensive disease.
Ferrario et al. (Thu,) conducted a review in Essential hypertension. Angiotensin II / ACE inhibitors was evaluated. A review of the renin-angiotensin-aldosterone system suggests that local synthesis of angiotensin peptides, particularly in the brain, may contribute to the development of hypertensive disease.