Key result
A review of the renin-angiotensin-aldosterone system suggests that local synthesis of angiotensin peptides, particularly in the brain, may contribute to the development of hypertensive disease.
This review highlights the local tissue synthesis of angiotensin peptides and proposes that a defect in the brain renin-angiotensin-aldosterone system may play a role in the development of hypertension.
Should not change hypertension management; leaves open brain RAAS as a mechanistic target for future studies.
Angiotensin II has long been recognized as a key factor in cardiovascular regulation. The effectiveness of angiotensin-converting enzyme (ACE) inhibitors in controlling essential hypertension suggests that angiotensin II plays a key role in its pathology. The tools of molecular biology have provided the means for a critical reassessment of the renin-angiotensin-aldosterone system in physiology and pathology. The analysis has shown that angiotensin peptides are also synthesized and processed locally in a variety of tissues, including the vascular wall, adrenal glands, heart, and brain. Since angiotensin II is a potent modulator of cardiovascular control centers in the brain, the hypothesis is now advanced that a defect in the brain renin-angiotensin-aldosterone system contributes to the development of hypertensive disease.
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Ferrario et al. (1989) conducted a review in Essential hypertension. Angiotensin II / ACE inhibitors was evaluated. A review of the renin-angiotensin-aldosterone system suggests that local synthesis of angiotensin peptides, particularly in the brain, may contribute to the development of hypertensive disease.
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