Key result
ACE inhibitors and angiotensin II receptor antagonists are effective for treating hypertension and heart failure, and may prevent atherosclerosis and glomerulosclerosis.
This review highlights the pharmacological mechanisms and therapeutic benefits of ACE inhibitors and ARBs in managing hypertension, heart failure, and potentially preventing atherosclerosis and glomerulosclerosis.
Answers are grounded in this paper and cite their sources.
Supports ACEI/ARB use in hypertension and heart failure; leaves open preventive effects on atherosclerosis and glomerulosclerosis.
Recent developments in the techniques of molecular biology and the availability of inhibitors of the renin-angiotensin system have provided new insight into renin-angiotensin research. The control mechanism of renin release and the metabolism of circulating renin have been well characterized on the molecular level. Angiotensin II has been shown to play an important role not only in the regulation of blood pressure but also in cell growth and hypertrophy. ACE inhibitors are effective for the treatments of hypertension and heart failure. Furthermore, recent studies suggest that ACE inhibitors may prevent atherosclerosis and glomerulosclerosis. Angiotensin II receptor antagonists have similar beneficial effects. These effects of ACE inhibitors and angiotensin II-receptor antagonists may be mediated by growth factors and the extracellular matrix.
No takes yet. Share an insight, caveat, or question.
山本 研二郎 (1994) conducted a review in Hypertension and heart failure. ACE inhibitors and Angiotensin II receptor antagonists was evaluated. ACE inhibitors and angiotensin II receptor antagonists are effective for treating hypertension and heart failure, and may prevent atherosclerosis and glomerulosclerosis.
Synapse has enriched 10 related papers. Consider them for comparative context: