Do new angiotensin II receptor 1 antagonists (compounds 1b and 2b) reduce blood pressure in spontaneously hypertensive rats compared to Losartan?
Compounds 1b and 2b are novel angiotensin II receptor 1 antagonists that demonstrate antihypertensive efficacy comparable or superior to Losartan in preclinical models.
A series of new angiotensin II receptor 1 antagonists were prepared. They displayed nanomolar affinity to AT1 receptor and could decrease blood pressure efficiently in spontaneously hypertensive rats. Among them, compounds 1b and 2b could reduce the blood pressure with more or equal potency compared to Losartan. So, compounds 1b and 2b could be considered as potential antihypertension drug candidates.
Wu et al. (Mon,) studied this question.