Why the study?
Do new angiotensin II receptor 1 antagonists (compounds 1b and 2b) reduce blood pressure in spontaneously hypertensive rats compared to Losartan?
Do new angiotensin II receptor 1 antagonists (compounds 1b and 2b) reduce blood pressure in spontaneously hypertensive rats compared to Losartan?
Compounds 1b and 2b are novel angiotensin II receptor 1 antagonists that demonstrate antihypertensive efficacy comparable or superior to Losartan in preclinical models.
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Supports further preclinical optimization of these AT1 antagonists; leaves open clinical translation versus losartan.
Wu et al. (2018) studied this question.
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