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A series of new angiotensin II receptor 1 antagonists were prepared. They displayed nanomolar affinity to AT1 receptor and could decrease blood pressure efficiently in spontaneously hypertensive rats. Among them, compounds 1b and 2b could reduce the blood pressure with more or equal potency compared to Losartan. So, compounds 1b and 2b could be considered as potential antihypertension drug candidates.
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Wu et al. (Mon,) studied this question.
synapsesocial.com/papers/6a23f0d49e1c90a91c0975a5 — DOI: https://doi.org/10.1021/acsmedchemlett.8b00335
Zhuo Wu
Fudan University
Xiaolu Bao
Shanghai Ninth People's Hospital
Weibo Zhu
Donghua University
ACS Medicinal Chemistry Letters
Donghua University
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