Population
Preclinical models including rabbit aorta rings, conscious rats, and cynomolgus monkeys
Design
Preclinical
Authors
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Supports advancement of imidazolone AT1 antagonists to clinical testing; leaves open confirmation of efficacy and safety in humans.
A new series of imidazolones, particularly compound 21 (SR 47436), demonstrated potent AT1 receptor antagonism in preclinical models, leading to clinical trials for hypertension.
BERNHART et al. (1993) studied this question.
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