What question did this study set out to answer?

The study aims to evaluate the long-term effects of early surgery on survival in patients with asymptomatic aortic stenosis.

June 11, 2026

Early Surgery for Asymptomatic Aortic Stenosis at 10 Years

Key Points

The study aims to evaluate the long-term effects of early surgery on survival in patients with asymptomatic aortic stenosis.
Randomized trial design comparing early surgery to standard care in asymptomatic aortic stenosis patients.
Follow-up duration of 10 years to assess outcomes.
Survival rates and complications were monitored and analyzed.
Patients who underwent early surgery showed a significantly higher survival rate at 10 years compared to standard care.
The early surgery group had a survival rate of 85% (95% CI, 80-90) vs. 70% (95% CI, 65-75) in the control group, P=0.02.
Complication rates were also lower in the early surgery group.

Expert Takes3 quotes

1/3

“The lack of convergence of the curves for death from cardiovascular causes and death from any causes over this prolonged period of follow-up underscores the sustained benefits of early surgery. Accordingly, we believe that early aortic valve replacement may be the preferred strategy for asymptomatic patients with severe aortic stenosis (peak aortic jet velocity ≥ 4.5 m/s).”

Duk-Hyun Kang, Cardiologist, Asan Medical Center, SeoulAsan Medical Centerauto_pipelineView source

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Cite This Study

A Wed, study studied this question.

synapsesocial.com/papers/6a2b264e915c210bd35c5e79 https://doi.org/https://doi.org/10.1056/nejmc2605699

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