Inhibition of Amyloid-β and α-Synuclein Oligomer-induced NLRP3 Inflammasome Activation by NDGA in Microglia: A Promising Anti-inflammatory Strategy for Neurodegeneration (S1.010)

Key Points

• The central aim is to assess the effect of NDGA on NLRP3 inflammasome activation triggered by amyloid-β and α-synuclein in microglial cells.
• Exposure of microglial cells to amyloid-β and α-synuclein oligomers
• Treatment with NDGA to evaluate its inhibitory effect on inflammasome activation
• NDGA significantly reduced NLRP3 inflammasome activation in treated microglial cells.
• Inhibition of pro-inflammatory mediators was observed following NDGA treatment.