Demonstrates reduced NLRP3 inflammasome activation in microglia, suggesting NDGA as a potential therapy for neurodegeneration.
This study aimed to determine whether nordihydroguaiaretic acid (NDGA) can reduce NLRP3 inflammasome activation in microglial cells exposed to amyloid-β (Aβ) and α-synuclein (α-syn) oligomers.
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Hoang et al. (2026) studied this question.
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