What question did this study set out to answer?

The expression of concern addresses potential data integrity issues in the original research involving serelaxin signaling in vascular cells.

June 13, 2026

EXPRESSION OF CONCERN: Serelaxin‐Mediated Signal Transduction in Human Vascular Cells: Bell‐Shaped Concentration–Response Curves Reflect Differential Coupling to G Proteins

Key Points

The expression of concern addresses potential data integrity issues in the original research involving serelaxin signaling in vascular cells.
Issue raised by third parties regarding figure presentation in the publication.
Identified discrepancies in loading control blots in experiments with different cell lines.
Corresponding author acknowledged unintentional errors in figure preparation.
Concerns cannot be resolved due to the lack of underlying raw data.
The corresponding author maintains that results and conclusions are unaffected by the acknowledged errors.

Abstract

EXPRESSION OF CONCERN: M. Sarwar, C. S. Samuel, R. A. Bathgate, D. R. Stewart, and R. J. Summers, “ Serelaxin-Mediated Signal Transduction in Human Vascular Cells: Bell-Shaped Concentration–Response Curves Reflect Differential Coupling to G Proteins,” British Journal of Pharmacology 172, no. 4 (2014): 1005–1019, https://doi.org/10.1111/bph.12964 This Expression of Concern is for the above article, published online on 8 October 2014 in Wiley Online Library (wileyonlinelibrary.com), and has been issued by agreement between the journal Editor-in-Chief, Péter Ferdinandy; the British Pharmacological Society; and John Wiley however, due to the time elapsed since the article's original publication, the underlying raw data are no longer available to correct the issue. The corresponding author maintains that the results and conclusions of the article are not affected. However, as the identified concerns cannot be resolved, the journal has decided to issue an Expression of Concern to inform and alert readers.

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